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L-Phenylalanine

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L-Phenylalanine

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Description

Phenylalanine is an essential amino acid that plays a critical role in protein biosynthesis and neurological health. Naturally found in many protein-rich foods, it is also available in synthetic form for nutritional and industrial use. The most common form is L-Phenylalanine, which is biologically active and often used in dietary supplements and pharmaceutical applications.

It serves as a precursor to tyrosine, which in turn supports the production of neurotransmitters such as dopamine, norepinephrine, and epinephrine. Due to its role in brain function and mood regulation, L-Phenylalanine is frequently used in brain health supplements and therapeutic formulations.

Other names: (S)-2-amino-3-phenylpropanoic acid

 
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Additional information

CAS#

63-91-2
Formula

C9H11NO2

Properties

Chemical Properties of L-Phenylalanine

CAS Number 63-91-2
Chemical Formula C₉H₁₁NO₂
Molar Mass 165.19 g/mol
Solubility Slightly soluble in water
Appearance White to off-white crystalline powder
Odor Odorless
Melting Point 270–275 °C (decomposes)
Density ~1.29 g/cm³
Boiling Point Not applicable (decomposes)
Stability Stable under normal temperatures and pressures
Flash Point Non-flammable

Applications

Applications of L-Phenylalanine

Phenylalanine’s benefits and applications make it useful across a wide range of industries, including:

  • Nutraceuticals & Supplements
    Used in dietary formulas to support mood, alertness, and mental clarity. 
  • Pharmaceuticals
    A precursor in the synthesis of medications that treat depression and chronic pain. 
  • Food & Beverage Industry
    As a building block for artificial sweeteners and functional food fortification. 
  • Medical Nutrition
    Applied in therapeutic nutrition for patients with certain metabolic disorders. 
  • Cosmetic Formulations
    Occasionally incorporated into skincare products for its antioxidant properties.

Benefits

Benefits of L-Phenylalanine

Phenylalanine offers various functional and therapeutic benefits depending on the application and industry. 

Below are key phenylalanine benefits, categorized by industry:

Nutritional & Brain Health Benefits

  • Supports the production of key neurotransmitters (dopamine, norepinephrine)
  • May aid in mood regulation and mental focus
  • Commonly used in nootropic and brain health supplements

Pharmaceutical Benefits

  • Used in treatments for depression, ADHD, and chronic pain
  • May support the management of vitiligo and certain skin pigment conditions

Sports & Weight Management Supplements

  • Plays a role in reducing appetite by increasing satiety-related neurotransmitters
  • Sometimes included in performance supplements for cognitive support

Cosmetic & Skincare Applications

  • Offers antioxidant-like effects that may help protect the skin from environmental stress
  • May support melanin production and skin tone balance

Hazard Measures

Hazards Identification and Transport Information

  • Hazard Classification: Not classified as hazardous under GHS regulations.
  • Environmental Hazards: None known in standard industrial quantities.
  • Transportation Classification: Not classified as dangerous goods under ADR/RID, DOT, IATA, or IMDG.

First Aid Measures and Accidental Release

First Aid Measures

  • Inhalation: Move to fresh air and seek medical attention if symptoms persist.
  • Skin Contact: Wash with soap and water. Remove contaminated clothing.
  • Eye Contact: Rinse thoroughly with water for several minutes.
  • Ingestion: Rinse mouth. Do not induce vomiting unless advised by a professional.

Accidental Release Measures

  • Sweep or vacuum without creating dust
  • Avoid contact with skin and eyes
  • Dispose of in accordance with local regulations

Handling and Storage

Handling and Storage of L-Phenylalanine

  • Handling Guidelines: 
    • Use in a well-ventilated area
    • Wear appropriate protective equipment 
  • Storage Guidelines: 
    • Keep container tightly closed
    • Store in a cool, dry place
    • Avoid exposure to heat and moisture

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